From: [d b lake] at [eureka.wbme.jhu.edu] (Dave Blake)
Newsgroups: talk.politics.drugs
Subject: Re: The Great ... References
Date: 13 Mar 1995 13:48:23 GMT
Mime-Version: 1.0

Authors                                                                     
 Heishman SJ.  Huestis MA.  Henningfield JE.  Cone EJ.                      
Institution                                                                 
 Clinical Pharmacology Branch, National Institute on Drug Abuse,    
 Baltimore,  MD 21224.                                                      
Title                                                                       
 Acute and residual effects of marijuana: profiles of plasma THC levels,    
 physiological, subjective, and performance measures.                       
Source                                                                      
 Pharmacology, Biochemistry & Behavior.  37(3):561-5, 1990 Nov.            
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 Abstract                                                                   
  Three experienced marijuana smokers participated in four 2-day            
  experimental sessions in which they smoked either 0, 1, or 2 marijuana    
  cigarettes containing 2.57% delta 9-tetrahydrocannabinol (THC) at two     
  different times on the first day. A battery of physiological, subjective, 
  and performance measures was repeated throughout day 1 to assess acute    
  effects and on day 2 to measure any residual effects of marijuana. Blood  
  samples were also repeatedly collected to examine the relationship    
  between plasma levels and pharmacological effects of THC. Acutely,        
  marijuana impaired performance on a circular lights task in all        
  subjects. Performance was also impaired (decreased accuracy and        
  increased response  time) on serial addition/subtraction and digit        
  recall tasks on day 1 in two subjects. On day 2, tachycardia and        
  subjective effects of marijuana were not observed. Performance remained   
  impaired on the arithmetic and recall tasks on day 2, although the        
  decrements were not as large as those observed on day 1. In general,      
  plasma THC levels covaried with the other measures. These preliminary     
  results suggest that marijuana can adversely affect complex human        
  performance up to 24 hours after smoking.