From: [a--l--n] at [pomona.claremont.edu]
Newsgroups: alt.drugs
Subject: Re: Ketamine
Date: Sat, 06 Nov 1993 21:41:16 GMT

[j--r--y] at [teetot.acusd.edu] (Jerry Stratton) writes:
>Ketamine is a variation on PCP, and is practically the same thing. 

Um, not unless you have a _real_ loose definition of being the same:

Ketamine: 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
PCP: 1-(1-Phenylcyclohexyl)piperidine

I'd give the structures, but my ASCII renderings suck.  But they don't even
have the same number of rings, and not very many functional groups in common. 
They're completely different substances.

peace, tony


====
Newsgroups: alt.drugs
From: [d--r] at [spdcc.com] (Steve Dyer)
Subject: Re: Ketamine
Date: Sat, 6 Nov 1993 22:26:33 GMT

[a--l--n] at [pomona.claremont.edu] writes:
>>Ketamine is a variation on PCP, and is practically the same thing. 
>
>Um, not unless you have a _real_ loose definition of being the same:
>
>Ketamine: 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
>PCP: 1-(1-Phenylcyclohexyl)piperidine
>
>I'd give the structures, but my ASCII renderings suck.  But they don't even
>have the same number of rings, and not very many functional groups in common. 
>They're completely different substances.

Both are dissociative anaesthetics.  Both are based on a phenyl group and
a substituted amino group attached to the same cyclohexyl carbon.  Ketamine
was synthesized in a search for less toxic analogues of PCP.  The structural
similarity between the two is obvious even to someone who isn't a
pharmaceutical chemist.  They are different substances, but they're
clearly in the same chemical and pharmacological families.

-- 
Steve Dyer
[d--r] at [ursa-major.spdcc.com]