From: [REDACTED] at [O.M] (Sir William Osler)
Newsgroups: alt.drugs.hard
Subject: Re: Heroin Nausea
Date: Thu, 02 Nov 95 21:26:43 GMT

[p--t--r] at [petermc.demon.co.uk] (Peter McDermott) wrote:
>[s--i--e] at [psuedonym.com] (Spike) wrote:
>>Does anyone know why dope causes nausea?It doesn't seem to make a
>I'm not sure why it causes nausea, but it may be for the same
>reason that it causes constipation. Apparently, there are lots
>of endorphin receptors in the stomach and gut.

From Goodman and Gilman (1967) "The nauseant and emetic effects of morphine 
and its derivatives are ... caused by direct stimulation of the CTZ in the 
area of the postrema of the medulla...Certain individuals never vomit after 
morphine, whereas others do so each time the drug is administered. Nausea  and 
vomiting are relatively uncommon in recumbent patients...but...nausea occurs 
in approx 40% and vomiting in 16% of ambulatory patients given 15mg 
subcutaneously....In addition to stimulating the CTZ, MORPHINE DEPRESSES THE 
VOMITING CENTER {of the brain...emphasis original}. Thus after therapeutic 
doses of morphine, subsequent doses of the drug are unlikely to produce 
vomiting; other emetics are also ineffective after morphine. All clinically 
useful narcotic analgesics produce some degree of nausea and vomiting."

Don't know how I ever lived without this tome...wish I had an up to date 
edition...








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