Newsgroups: alt.drugs
From: [d--uh--i] at [efn.org] (Darrell Fuhriman)
Subject: METHADONE: Hazardous Materials Data Sheet
Date: Wed, 17 Nov 1993 09:24:53 GMT
*--* 11-15-93 - 11:59:47 *--*
1 OHS14132 PAGE 001 OF 006
MATERIAL SAFETY DATA SHEET
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OCCUPATIONAL HEALTH SERVICES, INC. FOR EMERGENCY SOURCE INFORMATION
11 WEST 42ND STREET, 12TH FLOOR CONTACT: 1-615-366-2000
NEW YORK, NEW YORK 10036
1-800-445-MSDS (1-800-445-6737) OR
1-212-789-3535
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SUBSTANCE IDENTIFICATION
CAS NUMBER: 1095-90-5
RTECS NUMBER: MJ6300000
SUBSTANCE: METHADONE HYDROCHLORIDE
TRADE NAMES/SYNONYMS:
3-HEPTANONE, 6-(DIMETHYLAMINO)-4,4-DIPHENYL-, HYDROCHLORIDE;
6-(DIMETHYLAMINO)-4,4-DIPHENYL-3-HEPTANONE HYDROCHLORIDE;
ADANON HYDROCHLORIDE; AMIDON HYDROCHLORIDE; DIAMINON HYDROCHLORIDE;
DOLOPHINE HYDROCHLORIDE; MECODIN; MEPHENON; MOHEPTAN; PHYSEPTONE; METHADONE;
C21H28CLNO; OHS14132
CHEMICAL FAMILY:
KETONE, ALKYL-ARYL
AMINE
MOLECULAR FORMULA: C21-H27-N-O.H-CL
MOLECULAR WEIGHT: 345.91
CERCLA RATINGS (SCALE 0-3): HEALTH=3 FIRE=1 REACTIVITY=0 PERSISTENCE=2
NFPA RATINGS (SCALE 0-4): HEALTH=3 FIRE=1 REACTIVITY=0
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COMPONENTS AND CONTAMINANTS
COMPONENT: METHADONE HYDROCHLORIDE PERCENT: 100
CAS# 1095-90-5
OTHER CONTAMINANTS: NONE
EXPOSURE LIMITS:
NO OCCUPATIONAL EXPOSURE LIMITS ESTABLISHED BY OSHA, ACGIH, OR NIOSH.
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PHYSICAL DATA
DESCRIPTION: CRYSTALLINE SOLID WITH A BITTER TASTE.
MELTING POINT: 455-457 F (235-236 C) SPECIFIC GRAVITY: NOT AVAILABLE
PH: 4.5-5.6 @ 1% SOLN SOLUBILITY IN WATER: 12%
SOLVENT SOLUBILITY: SOLUBLE IN ALCOHOL, ETHER, CHLOROFORM, ISOPROPANOL;
INSOLUBLE IN ETHER, GLYCEROL.
1 OHS14132 PAGE 002 OF 006
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FIRE AND EXPLOSION DATA
FIRE AND EXPLOSION HAZARD:
SLIGHT FIRE HAZARD WHEN EXPOSED TO HEAT OR FLAME.
FIREFIGHTING MEDIA:
DRY CHEMICAL, CARBON DIOXIDE, WATER SPRAY OR REGULAR FOAM
(1990 EMERGENCY RESPONSE GUIDEBOOK, DOT P 5800.5).
FOR LARGER FIRES, USE WATER SPRAY, FOG OR REGULAR FOAM
(1990 EMERGENCY RESPONSE GUIDEBOOK, DOT P 5800.5).
FIREFIGHTING:
MOVE CONTAINER FROM FIRE AREA IF YOU CAN DO IT WITHOUT RISK (1990 EMERGENCY
RESPONSE GUIDEBOOK, DOT P 5800.5, GUIDE PAGE 53).
EXTINGUISH USING AGENT SUITABLE FOR TYPE OF SURROUNDING FIRE. AVOID BREATHING
VAPORS AND DUSTS. KEEP UPWIND.
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TRANSPORTATION DATA
DEPARTMENT OF TRANSPORTATION HAZARD CLASSIFICATION 49-CFR 172.101:
POISON B
DEPARTMENT OF TRANSPORTATION LABELING REQUIREMENTS 49-CFR 172.101 AND
SUBPART E:
POISON
DEPARTMENT OF TRANSPORTATION PACKAGING REQUIREMENTS: 49-CFR 173.365
EXCEPTIONS: 49-CFR 173.364
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TOXICITY
METHADONE HYDROCHLORIDE:
TOXICITY DATA: 1430 UG/KG ORAL-HUMAN LDLO; 5 MG/KG ORAL-CHILD LDLO;
30 MG/KG ORAL-RAT LD50; 124 MG/KG ORAL-MOUSE LD50; 12 MG/KG SUBCUTANEOUS-RAT
LD50; 34 MG/KG SUBCUTANEOUS-MOUSE LD50; 54 MG/KG SUBCUTANEOUS-GUINEA
PIG LD50; 10 MG/KG SUBCUTANEOUS-MONKEY LD50; 9200 UG/KG INTRAVENOUS-RAT
LD50; 16 MG/KG INTRAVENOUS-MOUSE LD50; 11 MG/KG INTRAPERITONEAL-RAT
LC50; 8300 UG/KG INTRAPERITONEAL-MOUSE LD50; MUTAGENIC DATA (RTECS);
REPRODUCTIVE EFFECTS DATA (RTECS).
CARCINOGEN STATUS: NONE.
ACUTE TOXICITY LEVEL: HIGHLY TOXIC BY INGESTION.
TARGET EFFECTS: CENTRAL NERVOUS SYSTEM DEPRESSANT. POISONING MAY ALSO AFFECT
THE RESPIRATORY, CARDIOVASCULAR AND GASTROINTESTINAL SYSTEMS.
ADDITIONAL DATA: THE USE OF ALCOHOLIC BEVERAGES MAY ENHANCE THE TOXIC EFFECTS.
PERFORMANCE OF TASKS REQUIRING ALERTNESS MAY BE IMPAIRED. INTERACTIONS
WITH MEDICATIONS HAVE BEEN REPORTED.
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HEALTH EFFECTS AND FIRST AID
1 OHS14132 PAGE 003 OF 006
INHALATION:
METHADONE HYDROCHLORIDE:
ACUTE EXPOSURE- MAY CAUSE SYSTEMIC EFFECTS AS DETAILED IN ACUTE INGESTION.
CHRONIC EXPOSURE- MAY CAUSE SYSTEMIC EFFECTS AS DETAILED IN CHRONIC
INGESTION.
FIRST AID- REMOVE FROM EXPOSURE AREA TO FRESH AIR IMMEDIATELY. IF BREATHING
HAS STOPPED, GIVE ARTIFICIAL RESPIRATION. MAINTAIN AIRWAY AND BLOOD
PRESSURE AND ADMINISTER OXYGEN IF AVAILABLE. KEEP AFFECTED PERSON WARM AND
AT REST. TREAT SYMPTOMATICALLY AND SUPPORTIVELY. ADMINISTRATION OF OXYGEN
SHOULD BE PERFORMED BY QUALIFIED PERSONNEL. GET MEDICAL ATTENTION
IMMEDIATELY.
SKIN CONTACT:
METHADONE HYDROCHLORIDE:
ACUTE EXPOSURE- SYSTEMIC ADMINISTRATION OF NARCOTIC ANALGESICS MAY CAUSE
RASHES, PRURITUS, URTICARIA, EDEMA AND RARELY HEMORRHAGIC URTICARIA.
CHRONIC EXPOSURE- NO DATA AVAILABLE.
FIRST AID- REMOVE CONTAMINATED CLOTHING AND SHOES IMMEDIATELY. WASH AFFECTED
AREA WITH SOAP OR MILD DETERGENT AND LARGE AMOUNTS OF WATER UNTIL NO
EVIDENCE OF CHEMICAL REMAINS (APPROXIMATELY 15-20 MINUTES). GET MEDICAL
ATTENTION IMMEDIATELY.
EYE CONTACT:
METHADONE HYDROCHLORIDE:
ACUTE EXPOSURE- ONE INCIDENT OF REVERSIBLE CORTICAL BLINDNESS, APPARENTLY
SECONDARY TO ANOXIA, HAS BEEN REPORTED AFTER INGESTION OF METHADONE.
SYSTEMIC ADMINISTRATION MAY CAUSE MIOSIS. IN MICE, IT RESULTED IN THE
RAPID APPEARANCE OF OPACITIES OF THE LENS DUE TO SUPPRESSION OF BLINKING
WITH RESULTANT DRYING OF THE CORNEA AND DEHYDRATION OF THE LENS. THE
EFFECT WAS REVERSIBLE.
CHRONIC EXPOSURE- NO DATA AVAILABLE.
FIRST AID- WASH EYES IMMEDIATELY WITH LARGE AMOUNTS OF WATER OR NORMAL SALINE,
OCCASIONALLY LIFTING UPPER AND LOWER LIDS, UNTIL NO EVIDENCE OF CHEMICAL
REMAINS (APPROXIMATELY 15-20 MINUTES). GET MEDICAL ATTENTION IMMEDIATELY.
INGESTION:
METHADONE HYDROCHLORIDE:
NARCOTIC/HIGHLY TOXIC.
ACUTE EXPOSURE- THE ESTIMATED LETHAL DOSE IN HUMANS IS 0.1 GRAMS.
INGESTION OF NARCOTIC ANALGESICS MAY CAUSE DRY MOUTH, SLURRED
SPEECH, HEADACHE, NAUSEA, VOMITING, DIZZINESS, DROWSINESS, WEAKNESS,
ANOREXIA, INSOMNIA, DEPRESSED COUGH REFLEX, TREMORS, VISUAL DISTURBANCES
AND IMPAIRED MENTAL AND PHYSICAL PERFORMANCE. PRURITUS, SWEATING AND
SLIGHT DECREASE IN BODY TEMPERATURE MAY OCCUR. THERE MAY BE MOOD
CHANGES AND EUPHORIA, SEDATION, DYSPHORIA AND APATHY ARE POSSIBLE. IN
SOME INDIVIDUALS ANXIETY, AGITATION AND EXCITEMENT MAY PASS INTO
DELIRIUM OR MANIA. HALLUCINATIONS HAVE BEEN REPORTED. ANALGESIA AND
INCREASED PAIN TOLERANCE MAY OCCUR, BUT AS THE ANALGESIA WEARS OFF
THERE MAY BE AN INCREASED SENSITIVITY TO PAIN. WITH HIGHER DOSES, THE
CENTRAL NERVOUS SYSTEM DEPRESSION MAY PROGRESS WITH STUPOR,
UNCONSCIOUSNESS AND COMA IN WHICH THE PUPILS BECOME PINPOINT AND
SKELETAL MUSCLES ARE FLACCID, ALTHOUGH POSITIVE BABINSKI REFLEXES AND
MUSCLE TWITCHING MAY OCCUR. THERE MAY BE CONVULSIONS, ESPECIALLY WITH
HYPOXEMIA. RESPIRATORY DEPRESSION MAY OCCUR WITH SLOW, SHALLOW,
1 OHS14132 PAGE 004 OF 006
IRREGULAR BREATHING, APNEA AND RESULTANT HYPOXEMIA AND CYANOSIS.
PULMONARY EDEMA IS COMMON. OTHER EFFECTS ON THE RESPIRATORY SYSTEM MAY
INCLUDE BRONCHOSPASM AND ASPIRATION PNEUMONIA. PERIPHERAL VASODILATION
MAY RESULT IN THE SKIN OF THE FACE, NECK AND UPPER THORAX BECOMING
FLUSHED AND WARM, AND IN SYNCOPE FROM ORTHOSTATIC HYPOTENSION. MORE
SERIOUS EFFECTS ON THE CARDIOVASCULAR SYSTEM MAY INCLUDE HYPERTENSION,
ARRHYTHMIAS, SHOCK, ACUTE VENTRICULAR FAILURE AND CARDIAC ARREST.
EFFECTS ON THE GASTROINTESTINAL SYSTEM MAY INCLUDE DECREASED GASTRIC
MOTILITY, CONSTIPATION, FECAL IMPACTION, CRAMPING, AND INCREASED
MUSCLE TONE OF THE GASTROINTESTINAL AND BILIARY TRACTS TO THE POINT
OF SPASM. DEPRESSED URINE FORMATION AND URINARY RETENTION MAY OCCUR.
THE LIVER MAY BE ENLARGED AND TENDER AND LIVER FUNCTION TESTS MAY BE
ABNORMAL. OTHER LAB FINDINGS MAY INCLUDE MILD LEUKOCYTOSIS WITH
LYMPHOCYTOSIS, ACIDOSIS AND HYPOGLYCEMIA. DEATH IS ALMOST ALWAYS DUE TO
RESPIRATORY FAILURE. METHADONE CROSSES THE PLACENTA AND IS EXCRETED IN
HUMAN BREAST MILK.
CHRONIC EXPOSURE- CHRONIC ADMINISTRATION OF METHADONE MAY RESULT IN
EXCESSIVE SWEATING, LYMPHOCYTOSIS, AND INCREASED CONCENTRATIONS OF
PROLACTIN, ALBUMIN AND GLOBULINS IN THE PLASMA. REPEATED USE OF NARCOTIC
ANALGESICS HAS BEEN ASSOCIATED WITH VARIOUS PULMONARY PATHOLOGIES,
ABNORMAL PULMONARY FUNCTION, MYOGLOBINURIA, RENAL FAILURE AND CARDIAC
ARRYTHMIAS. DIRECT NEUROLOGICAL EFFECTS FROM CHRONIC USE HAVE NOT BEEN
REPORTED. TOLERANCE AND PHYSICAL DEPENDENCE MAY DEVELOP. SYMPTOMS OF
WITHDRAWAL MAY OCCUR. EFFECTS ON THE FETUS AND NEWBORN MAY INCLUDE
ADDICTION, WITHDRAWAL AND DEATH. IN ANIMAL STUDIES, EFFECTS ON THE EMBRYO
OR FETUS AND THE NEWBORN HAVE BEEN REPORTED FROM REPEATED ADMINISTRATION
OF METHADONE TO FEMALE RATS PRIOR TO MATING AND DURING PREGNANCY AND
LACTATION AND TO MALE RATS PRIOR MATING.
FIRST AID- REMOVE BY GASTRIC LAVAGE. PROTECT AGAINST ASPIRATION. EMETICS ARE
RARELY SUCCESSFUL AND ARE POTENTIALLY DANGEROUS. LEAVE 15-30 GRAMS OF SODIUM
SULFATE IN THE STOMACH AS A SALINE CATHARTIC AND A SLURRY OF ACTIVATED
CHARCOAL. MAINTAIN AIRWAY, RESPIRATION AND BLOOD PRESSURE. USE OXYGEN AND
PERFORM ARTIFICIAL RESPIRATION IF INDICATED (GOSSELIN, CLINICAL TOXICOLOGY
OF COMMERCIAL PRODUCTS, 5TH ED.).
ANTIDOTE:
THE FOLLOWING ANTIDOTE HAS BEEN RECOMMENDED. HOWEVER, THE DECISION AS TO
WHETHER THE SEVERITY OF POISONING REQUIRES ADMINISTRATION OF ANY ANTIDOTE AND
ACTUAL DOSE REQUIRED SHOULD BE MADE BY QUALIFIED MEDICAL PERSONNEL.
FOR OVERDOSES OF NARCOTIC ANALGESICS:
ADMINISTER NALOXONE HYDROCHLORIDE (NARCAN), 0.01 MG/KG INTRAVENOUSLY.
REPEAT INJECTION ONLY AS NECESSARY TO MAINTAIN RESPONSE TO STIMULI. IF
AN EFFECTIVE INCREASE IN PULMONARY VENTILATION IS NOT ACHIEVED WITH THE
FIRST DOSE, THE DOSE MAY BE REPEATED EVERY 2-3 MINUTES UNTIL RESPIRATION
RETURNS TO NORMAL AND THE PATIENT RESPONDS TO STIMULI. THE DOSE MAY NEED TO
BE 0.1-0.2 MG/KG IN MASSIVE OVERDOSES. IN ADDICTS OR NEWBORNS OF ADDICTED
MOTHERS, INJECTION OF NALOXONE CAN PRECIPITATE ACUTE, SEVERE WITHDRAWAL.
NALOXONE DOES NOT ANTAGONIZE CONVULSANT EFFECTS OF SOME NARCOTICS AND MAY
ENHANCE MEPERIDINE SEIZURES. (DREISBACH, HANDBOOK OF POISONING, 11TH ED.)
ANTIDOTE SHOULD BE ADMINISTERED BY MEDICAL PERSONNEL.
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REACTIVITY
REACTIVITY:
STABLE UNDER NORMAL TEMPERATURES AND PRESSURES.
1 OHS14132 PAGE 005 OF 006
INCOMPATIBILITIES:
METHADONE HYDROCHLORIDE:
NO DATA AVAILABLE.
DECOMPOSITION:
THERMAL DECOMPOSITION PRODUCTS MAY INCLUDE TOXIC OXIDES OF NITROGEN AND CARBON
AND TOXIC AND CORROSIVE FUMES OF CHLORIDES.
POLYMERIZATION:
HAZARDOUS POLYMERIZATION HAS NOT BEEN REPORTED TO OCCUR UNDER NORMAL
TEMPERATURES AND PRESSURES.
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STORAGE AND DISPOSAL
OBSERVE ALL FEDERAL, STATE AND LOCAL REGULATIONS WHEN STORING OR DISPOSING
OF THIS SUBSTANCE. FOR ASSISTANCE, CONTACT THE DISTRICT DIRECTOR OF THE
ENVIRONMENTAL PROTECTION AGENCY.
**STORAGE**
STORAGE OF CONTROLLED SUBSTANCES MUST COMPLY WITH APPLICABLE SECURITY
REQUIRMENTS IN 21 CFR 1301.71, 1301.72, 1301.73, 1301.74, 1301.75 AND 1301.76.
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CONDITIONS TO AVOID
MAY BURN BUT DOES NOT IGNITE READILY. PREVENT DISPERSION OF DUST IN AIR. DO
NOT ALLOW SPILLED MATERIAL TO CONTAMINATE WATER SOURCES.
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SPILL AND LEAK PROCEDURES
OCCUPATIONAL SPILL:
DO NOT TOUCH SPILLED MATERIAL. STOP LEAK IF YOU CAN DO IT WITHOUT RISK. FOR
SMALL SPILLS, TAKE UP WITH SAND OR OTHER ABSORBENT MATERIAL AND PLACE INTO
CONTAINERS FOR LATER DISPOSAL. FOR SMALL DRY SPILLS, WITH A CLEAN SHOVEL
PLACE MATERIAL INTO CLEAN, DRY CONTAINER AND COVER. MOVE CONTAINERS FROM
SPILL AREA. FOR LARGER SPILLS, DIKE FAR AHEAD OF SPILL FOR LATER DISPOSAL.
KEEP UNNECESSARY PEOPLE AWAY. ISOLATE HAZARD AREA AND DENY ENTRY.
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PROTECTIVE EQUIPMENT
VENTILATION:
PROVIDE LOCAL EXHAUST OR PROCESS ENCLOSURE VENTILATION SYSTEM.
RESPIRATOR:
THE FOLLOWING RESPIRATORS ARE RECOMMENDED BASED ON INFORMATION FOUND IN THE
PHYSICAL DATA, TOXICITY AND HEALTH EFFECTS SECTIONS. THEY ARE RANKED IN
ORDER FROM MINIMUM TO MAXIMUM RESPIRATORY PROTECTION.
THE SPECIFIC RESPIRATOR SELECTED MUST BE BASED ON CONTAMINATION LEVELS FOUND
IN THE WORK PLACE, MUST BE BASED ON THE SPECIFIC OPERATION, MUST NOT EXCEED
THE WORKING LIMITS OF THE RESPIRATOR AND MUST BE JOINTLY APPROVED BY THE
NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH AND THE MINE SAFETY
AND HEALTH ADMINISTRATION (NIOSH-MSHA).
1 OHS14132 PAGE 006 OF 006
ANY TYPE 'C' SUPPLIED-AIR RESPIRATOR WITH A FULL FACEPIECE OPERATED IN
PRESSURE-DEMAND OR OTHER POSITIVE PRESSURE MODE OR WITH A FULL FACEPIECE,
HELMET OR HOOD OPERATED IN CONTINUOUS-FLOW MODE.
ANY SELF-CONTAINED BREATHING APPARATUS WITH A FULL FACEPIECE OPERATED IN
PRESSURE-DEMAND OR OTHER POSITIVE PRESSURE MODE.
FOR FIREFIGHTING AND OTHER IMMEDIATELY DANGEROUS TO LIFE OR HEALTH CONDITIONS:
ANY SELF-CONTAINED BREATHING APPARATUS THAT HAS A FULL FACEPIECE AND IS
OPERATED IN A PRESSURE-DEMAND OR OTHER POSITIVE-PRESSURE MODE.
ANY SUPPLIED-AIR RESPIRATOR THAT HAS A FULL FACEPIECE AND IS OPERATED IN A
PRESSURE-DEMAND OR OTHER POSITIVE-PRESSURE MODE IN COMBINATION WITH AN
AUXILIARY SELF-CONTAINED BREATHING APPARATUS OPERATED IN PRESSURE-DEMAND
OR OTHER POSITIVE-PRESSURE MODE.
CLOTHING:
EMPLOYEE MUST WEAR APPROPRIATE PROTECTIVE (IMPERVIOUS) CLOTHING AND EQUIPMENT
TO PREVENT REPEATED OR PROLONGED SKIN CONTACT WITH THIS SUBSTANCE.
GLOVES:
EMPLOYEE MUST WEAR APPROPRIATE PROTECTIVE GLOVES TO PREVENT CONTACT WITH THIS
SUBSTANCE.
EYE PROTECTION:
EMPLOYEE MUST WEAR SPLASH-PROOF OR DUST-RESISTANT SAFETY GOGGLES TO PREVENT
EYE CONTACT WITH THIS SUBSTANCE.
EMERGENCY EYE WASH: WHERE THERE IS ANY POSSIBILITY THAT AN EMPLOYEE'S EYES MAY
BE EXPOSED TO THIS SUBSTANCE, THE EMPLOYER SHOULD PROVIDE AN EYE WASH
FOUNTAIN WITHIN THE IMMEDIATE WORK AREA FOR EMERGENCY USE.
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COPYRIGHT 1992 OCCUPATIONAL HEALTH SERVICES, INC.. ALL RIGHTS RESERVED.
CREATION DATE: 08/02/88 REVISION DATE: 06/04/92
--
Darrell Fuhriman
"Hi mom!"