Newsgroups: alt.drugs
From: [d--uh--i] at [efn.org] (Darrell Fuhriman)
Subject: MESCALINE:Hazardous Materials Data Sheet
Date: Wed, 17 Nov 1993 09:25:46 GMT
*--* 11-15-93 - 12:01:04 *--*
1
1 OHS14045 PAGE 001 OF 005
MATERIAL SAFETY DATA SHEET
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OCCUPATIONAL HEALTH SERVICES, INC. FOR EMERGENCY SOURCE INFORMATION
11 WEST 42ND STREET, 12TH FLOOR CONTACT: 1-615-366-2000
NEW YORK, NEW YORK 10036
1-800-445-MSDS (1-800-445-6737) OR
1-212-789-3535
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SUBSTANCE IDENTIFICATION
CAS NUMBER: 54-04-6
RTECS NUMBER: SI2625000
SUBSTANCE: MESCALINE
TRADE NAMES/SYNONYMS:
BENZENEETHANAMINE, 3,4,5-TRIMETHOXY-; 3,4,5-TRIMETHOXYBENZENEETHANAMINE;
PHENETHYLAMINE, 3,4,5-TRIMETHOXY-; 3,4,5-TRIMETHOXYPHENETHYLAMINE; MESCALIN;
MEZCALINE; 3,4,5-TRIMETHOXYPHENYLETHYLAMINE;
3,4,5-TRIMETHOXY-BETA-PHENETHYLAMINE; C11H17NO3; OHS14045
CHEMICAL FAMILY:
ALKALOID
MOLECULAR FORMULA: C11-H17-N-O3
MOLECULAR WEIGHT: 211.26
CERCLA RATINGS (SCALE 0-3): HEALTH=3 FIRE=1 REACTIVITY=0 PERSISTENCE=3
NFPA RATINGS (SCALE 0-4): HEALTH=3 FIRE=1 REACTIVITY=0
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COMPONENTS AND CONTAMINANTS
COMPONENT: MESCALINE PERCENT: 100
CAS# 54-04-6
OTHER CONTAMINANTS: NONE
EXPOSURE LIMITS:
NO OCCUPATIONAL EXPOSURE LIMITS ESTABLISHED BY OSHA, ACGIH, OR NIOSH.
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PHYSICAL DATA
DESCRIPTION: WHITE CRYSTALLINE SOLID.
BOILING POINT: 356 F (180 C) @ 12 MMHG MELTING POINT: 95-97 F (35-36 C)
SPECIFIC GRAVITY: NOT AVAILABLE SOLUBILITY IN WATER: SOLUBLE
SOLVENT SOLUBILITY: SOLUBLE IN ALCOHOL, BENZENE AND CHLOROFORM. PRACTICALLY
INSOLUBLE IN ETHER.
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FIRE AND EXPLOSION DATA
FIRE AND EXPLOSION HAZARD:
SLIGHT FIRE HAZARD WHEN EXPOSED TO HEAT OR FLAME.
1 OHS14045 PAGE 002 OF 005
FIREFIGHTING MEDIA:
DRY CHEMICAL, CARBON DIOXIDE, WATER SPRAY OR REGULAR FOAM
(1990 EMERGENCY RESPONSE GUIDEBOOK, DOT P 5800.5).
FOR LARGER FIRES, USE WATER SPRAY, FOG OR REGULAR FOAM
(1990 EMERGENCY RESPONSE GUIDEBOOK, DOT P 5800.5).
FIREFIGHTING:
MOVE CONTAINER FROM FIRE AREA IF YOU CAN DO IT WITHOUT RISK. DO NOT SCATTER
SPILLED MATERIAL WITH HIGH-PRESSURE WATER STREAMS. DIKE FIRE-CONTROL WATER FOR
LATER DISPOSAL (1990 EMERGENCY RESPONSE GUIDEBOOK, DOT P 5800.5, GUIDE
PAGE 31).
USE AGENTS SUITABLE FOR TYPE OF SURROUNDING FIRE. AVOID BREATHING HAZARDOUS
VAPORS, KEEP UPWIND.
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TOXICITY
MESCALINE:
2500 UG/KG INTRAMUSCULAR-HUMAN TDLO; 370 MG/KG INTRAPERITONEAL-RAT LD50;
534 MG/KG SUBCUTANEOUS-RAT LD50; 157 MG/KG INTRAVENOUS-RAT LD50; 330 MG/KG
INTRAMUSCULAR-RAT LD50; 880 MG/KG ORAL-MOUSE LD50; 315 MG/KG
INTRAPERITONEAL-MOUSE LD50; 534 MG/KG SUBCUTANEOUS-MOUSE LD50; 157 MG/KG
INTRAVENOUS-MOUSE LD50; 261 MG/KG UNREPORTED-MOUSE LD50; 500 MG/KG
SUBCUTANEOUS-GUINEA PIG LDLO; REPRODUCTIVE EFFECTS DATA (RTECS).
CARCINOGEN STATUS: NONE.
MESCALINE IS TOXIC PARENTERALLY. POISONING DUE TO PSYCHOTOMIMETIC AGENTS
MAY AFFECT THE CENTRAL NERVOUS SYSTEM. CROSS TOLERENCE BETWEEN DIFFERENT
PSYCHOTOMIMETIC AGENTS MAY OCCUR.
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HEALTH EFFECTS AND FIRST AID
INHALATION:
MESCALINE:
ACUTE EXPOSURE- NO DATA AVAILABLE.
CHRONIC EXPOSURE- NO DATA AVAILABLE.
FIRST AID- REMOVE FROM EXPOSURE AREA TO FRESH AIR IMMEDIATELY. IF BREATHING
HAS STOPPED, PERFORM ARTIFICIAL RESPIRATION. KEEP PERSON WARM AND AT REST.
TREAT SYMPTOMATICALLY AND SUPPORTIVELY. GET MEDICAL ATTENTION IMMEDIATELY.
SKIN CONTACT:
MESCALINE:
ACUTE EXPOSURE- NO DATA AVAILABLE.
CHRONIC EXPOSURE- NO DATA AVAILABLE.
FIRST AID- REMOVE CONTAMINATED CLOTHING AND SHOES IMMEDIATELY. WASH AFFECTED
AREA WITH SOAP OR MILD DETERGENT AND LARGE AMOUNTS OF WATER UNTIL NO
EVIDENCE OF CHEMICAL REMAINS (APPROXIMATELY 15-20 MINUTES). GET MEDICAL
ATTENTION IMMEDIATELY.
EYE CONTACT:
MESCALINE:
1 OHS14045 PAGE 003 OF 005
ACUTE EXPOSURE- A SINGLE RESEARCH REPORT DESCRIBES SPONTANEOUS ACTION
POTENTIALS WHICH APPEAR TO ORIGINATE IN THE RETINA AND ARE DETECTABLE
FROM THE EYE, THE OPTIC NERVE AND THE OCCIPITAL VISUAL CORTEX IN SEVERELY
POISONED CATS. NO OCULAR OR PERMANENT ALTERATION OF VISION HAS BEEN
REPORTED.
CHRONIC EXPOSURE- NO DATA AVAILABLE.
FIRST AID- WASH EYES IMMEDIATELY WITH LARGE AMOUNTS OF WATER OR NORMAL SALINE,
OCCASIONALLY LIFTING UPPER AND LOWER LIDS, UNTIL NO EVIDENCE OF CHEMICAL
REMAINS (APPROXIMATELY 15-20 MINUTES). GET MEDICAL ATTENTION IMMEDIATELY.
INGESTION:
MESCALINE:
ACUTE EXPOSURE- INGESTION OF PSYCHOTOMIMETIC AGENTS MAY CAUSE NAUSEA,
VOMITING, OCCASIONAL DIARRHEA, SWEATING, HEADACHE, HYPERTENSION,
TACHYCARDIA, TWITCHING, HYPERREFLEXIA, TREMORS AND INCOORDINATION.
BILATERALLY DILATED AND REACTIVE PUPILS, NYSTAGMUS, AND PHOTOPHOBIA MAY
OCCUR. VASODILATION, HYPOTENSION AND RESPIRATORY DEPRESSION MAY OCCUR
AT DOSES OF 20-60 MG/KG. BRADYCARDIA MAY BE PRESENT AT HIGHER DOSES.
CONVULSIONS AND COMA HAVE BEEN REPORTED. EFFECTS ON THE CENTRAL NERVOUS
SYSTEM MAY INCLUDE EUPHORIA, HYPEREXCITABILITY AND ALERTNESS, RAMBLING
SPEECH, DELIRIA, UNCONTROLLABILITY, TRANSCENDENTAL MOOD, DISTRACTABILITY,
DEPERSONALIZATION AND IMPAIRMENT OF JUDGEMENT. A TEMPORARY PSYCHOTIC
STATE WITH SENSORY ILLUSIONS, DISTORTIONS OR VISUAL HALLUCINATIONS
CONSISTING OF SHIMMERING INTENSIFICATION OF COLOR AND TEXTURE,
BRIGHTLY COLORED LIGHTS, GEOMETRIC DESIGNS, ANIMALS AND OCCASIONALLY
HUMAN IMAGES MAY OCCUR. HEARING OR TASTING COLORS AND SEEING SOUNDS HAVE
BEEN REPORTED. RARELY, ANXIETY, FEARFUL AUDITORY, VISUAL AND TACTILE
HALLUCINATIONS, PANIC STATES AND PARANOID DELUSIONS, SUSPICIOUSNESS,
EMOTIONAL LABILITY, INTENSE DEPRESSION, LOSS OF CONTROL, SUICIDAL
IDEATION AND SELF DESTRUCTIVE OR AGGRESSIVE ACTS MAY OCCUR. DEATHS
HAVE RESULTED FROM HALLUCINATORY EFFECTS LEADING TO ACCIDENTAL
DEATH OR CENTRAL NERVOUS SYSTEM AND RESPIRATORY DEPRESSION IN MASSIVE
INGESTIONS.
CHRONIC EXPOSURE- REPEATED EXPOSURE MAY CAUSE EFFECTS AS DETAILED IN
ACUTE INGESTION. FLASHBACKS WITH HALLUCINATIONS AND DISTORTION OF
PERCEPTION OF TIME, SPACE AND SELF IMAGE MAY OCCUR WEEKS OR MONTHS
AFTER THE LAST DOSE. TOLERENCE AND PSYCHOLOGIC DEPENDENCE MAY OCCUR.
SPECIFIC DEVELOPMENTAL ABNORMALITIES HAVE BEEN REPORTED FOLLOWING
INGESTION OF MESCALINE ON DAYS 7 THROUGH 10 OF PREGNANCY IN HAMSTERS.
FIRST AID- TREAT SYMPTOMATICALLY AND SUPPORTIVELY. GET MEDICAL ATTENTION
IMMEDIATELY. IF VOMITING OCCURS, KEEP HEAD LOWER THAN HIPS TO PREVENT
ASPIRATION.
ANTIDOTE:
NO SPECIFIC ANTIDOTE. TREAT SYMPTOMATICALLY AND SUPPORTIVELY.
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REACTIVITY
REACTIVITY:
STABLE UNDER NORMAL TEMPERATURES AND PRESSURES.
INCOMPATIBILITIES:
MESCALINE:
NO DATA AVAILABLE.
1 OHS14045 PAGE 004 OF 005
DECOMPOSITION:
THERMAL DECOMPOSITION PRODUCTS MAY INCLUDE TOXIC OXIDES OF CARBON AND
NITROGEN.
POLYMERIZATION:
HAZARDOUS POLYMERIZATION HAS NOT BEEN REPORTED TO OCCUR UNDER NORMAL
TEMPERATURES AND PRESSURES.
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STORAGE AND DISPOSAL
OBSERVE ALL FEDERAL, STATE AND LOCAL REGULATIONS WHEN STORING OR DISPOSING
OF THIS SUBSTANCE. FOR ASSISTANCE, CONTACT THE DISTRICT DIRECTOR OF THE
ENVIRONMENTAL PROTECTION AGENCY.
**STORAGE**
STORAGE OF CONTROLLED SUBSTANCES MUST COMPLY WITH APPLICABLE SECURITY
REQUIRMENTS IN 21 CFR 1301.71, 1301.72, 1301.73, 1301.74, 1301.75 AND 1301.76.
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CONDITIONS TO AVOID
MAY BURN BUT DOES NOT IGNITE READILY. AVOID CONTACT WITH STRONG OXIDIZERS,
EXCESSIVE HEAT, SPARKS, OR OPEN FLAME.
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SPILL AND LEAK PROCEDURES
OCCUPATIONAL SPILL:
STOP LEAK IF YOU CAN DO IT WITHOUT RISK. FOR SMALL SPILLS, TAKE UP WITH SAND
OR OTHER ABSORBENT MATERIAL AND PLACE INTO CLEAN, DRY CONTAINERS FOR LATER
DISPOSAL. KEEP UNNECESSARY PEOPLE AWAY. ISOLATE HAZARD AREA AND DENY ENTRY.
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PROTECTIVE EQUIPMENT
VENTILATION:
PROVIDE LOCAL EXHAUST OR GENERAL DILUTION VENTILATION SYSTEM.
RESPIRATOR:
THE FOLLOWING RESPIRATORS ARE RECOMMENDED BASED ON INFORMATION FOUND IN THE
PHYSICAL DATA, TOXICITY AND HEALTH EFFECTS SECTIONS. THEY ARE RANKED IN
ORDER FROM MINIMUM TO MAXIMUM RESPIRATORY PROTECTION.
THE SPECIFIC RESPIRATOR SELECTED MUST BE BASED ON CONTAMINATION LEVELS FOUND
IN THE WORK PLACE, MUST BE BASED ON THE SPECIFIC OPERATION, MUST NOT EXCEED
THE WORKING LIMITS OF THE RESPIRATOR AND MUST BE JOINTLY APPROVED BY THE
NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH AND THE MINE SAFETY
AND HEALTH ADMINISTRATION (NIOSH-MSHA).
ANY DUST AND MIST RESPIRATOR WITH A FULL FACEPIECE.
ANY AIR-PURIFYING FULL FACEPIECE RESPIRATOR WITH A HIGH-EFFICIENCY
PARTICULATE FILTER.
ANY POWERED AIR-PURIFYING RESPIRATOR WITH A TIGHT-FITTING FACEPIECE AND
1 OHS14045 PAGE 005 OF 005
HIGH-EFFICIENCY PARTICULATE FILTER.
ANY TYPE 'C' SUPPLIED-AIR RESPIRATOR WITH A FULL FACEPIECE OPERATED IN
PRESSURE-DEMAND OR OTHER POSITIVE PRESSURE MODE OR WITH A FULL FACEPIECE,
HELMET OR HOOD OPERATED IN CONTINUOUS-FLOW MODE.
ANY SELF-CONTAINED BREATHING APPARATUS WITH A FULL FACEPIECE OPERATED IN
PRESSURE-DEMAND OR OTHER POSITIVE PRESSURE MODE.
FOR FIREFIGHTING AND OTHER IMMEDIATELY DANGEROUS TO LIFE OR HEALTH CONDITIONS:
ANY SELF-CONTAINED BREATHING APPARATUS THAT HAS A FULL FACEPIECE AND IS
OPERATED IN A PRESSURE-DEMAND OR OTHER POSITIVE-PRESSURE MODE.
ANY SUPPLIED-AIR RESPIRATOR THAT HAS A FULL FACEPIECE AND IS OPERATED IN A
PRESSURE-DEMAND OR OTHER POSITIVE-PRESSURE MODE IN COMBINATION WITH AN
AUXILIARY SELF-CONTAINED BREATHING APPARATUS OPERATED IN PRESSURE-DEMAND
OR OTHER POSITIVE-PRESSURE MODE.
CLOTHING:
EMPLOYEE MUST WEAR APPROPRIATE PROTECTIVE (IMPERVIOUS) CLOTHING AND EQUIPMENT
TO PREVENT REPEATED OR PROLONGED SKIN CONTACT WITH THIS SUBSTANCE.
GLOVES:
EMPLOYEE MUST WEAR APPROPRIATE PROTECTIVE GLOVES TO PREVENT CONTACT WITH THIS
SUBSTANCE.
EYE PROTECTION:
EMPLOYEE MUST WEAR SPLASH-PROOF OR DUST-RESISTANT SAFETY GOGGLES TO PREVENT
EYE CONTACT WITH THIS SUBSTANCE.
EMERGENCY EYE WASH: WHERE THERE IS ANY POSSIBILITY THAT AN EMPLOYEE'S EYES MAY
BE EXPOSED TO THIS SUBSTANCE, THE EMPLOYER SHOULD PROVIDE AN EYE WASH
FOUNTAIN WITHIN THE IMMEDIATE WORK AREA FOR EMERGENCY USE.
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COPYRIGHT 1992 OCCUPATIONAL HEALTH SERVICES, INC.. ALL RIGHTS RESERVED.
CREATION DATE: 07/26/88 REVISION DATE: 10/12/92
--
Darrell Fuhriman
"Hi mom!"