Newsgroups: alt.drugs From: [d--uh--i] at [efn.org] (Darrell Fuhriman) Subject: LSD: Hazardous materials data sheet Date: Wed, 17 Nov 1993 09:21:22 GMT *--* 11-15-93 - 11:47:14 *--* 1 OHS13028 PAGE 001 OF 006 MATERIAL SAFETY DATA SHEET ------------------------------------------------------------------------------ OCCUPATIONAL HEALTH SERVICES, INC. FOR EMERGENCY SOURCE INFORMATION 11 WEST 42ND STREET, 12TH FLOOR CONTACT: 1-615-366-2000 NEW YORK, NEW YORK 10036 1-800-445-MSDS (1-800-445-6737) OR 1-212-789-3535 ------------------------------------------------------------------------------ SUBSTANCE IDENTIFICATION CAS NUMBER: 50-37-3 RTECS NUMBER: KE4100000 SUBSTANCE: LYSERGIC ACID DIETHYLAMIDE TRADE NAMES/SYNONYMS: ERGOLINE-8-CARBOXAMIDE, 9,10-DIDEHYDRO-N,N-DIETHYL-6-METHYL-, (8BETA)-; 9,10-DIDEHYDRO-N,N-DIETHYL-6-METHYLERGOLINE-8-CARBOXAMIDE; ERGOLINE-8(BETA)-CARBOXAMIDE, 9,10-DIDEHYDRO-N,N-DIETHYL-6-METHYL-; 9,10-DIDEHYDRO-N,N-DIETHYL-6-METHYLERGOLINE-8(BETA)-CARBOXAMIDE; DELYSID; N,N-DIETHYLLYSERGAMIDE; D-LSD; LSD-25; LSD; LSD (ALKALOID); (+)-LSD; D-LYSERGIC ACID DIETHYLAMIDE; LYSERGIDE; ACID; BLOTTER ACID; WINDOW PANES; 25; BLUE DOTS; THE BEAST; C20H25N3O; OHS13028 CHEMICAL FAMILY: ALKALOID MOLECULAR FORMULA: C20-H25-N3-O MOLECULAR WEIGHT: 323.48 CERCLA RATINGS (SCALE 0-3): HEALTH=3 FIRE=1 REACTIVITY=0 PERSISTENCE=3 NFPA RATINGS (SCALE 0-4): HEALTH=3 FIRE=1 REACTIVITY=0 ------------------------------------------------------------------------------ COMPONENTS AND CONTAMINANTS COMPONENT: LYSERGIC ACID DIETHYLAMIDE PERCENT: 100 CAS# 50-37-3 OTHER CONTAMINANTS: NONE EXPOSURE LIMITS: NO OCCUPATIONAL EXPOSURE LIMITS ESTABLISHED BY OSHA, ACGIH, OR NIOSH. ------------------------------------------------------------------------------ PHYSICAL DATA DESCRIPTION: TASTELESS, COLORLESS AND ODORLESS CRYSTALLINE SOLID. MELTING POINT: 176-185 F (80-85 C) SPECIFIC GRAVITY: NOT AVAILABLE SOLUBILITY IN WATER: SOLUBLE SOLVENT SOLUBILITY: SOLUBLE IN BENZENE. 1 OHS13028 PAGE 002 OF 006 ------------------------------------------------------------------------------ FIRE AND EXPLOSION DATA FIRE AND EXPLOSION HAZARD: SLIGHT FIRE HAZARD WHEN EXPOSED TO HEAT OR FLAME. FIREFIGHTING MEDIA: DRY CHEMICAL, CARBON DIOXIDE, WATER SPRAY OR REGULAR FOAM (1990 EMERGENCY RESPONSE GUIDEBOOK, DOT P 5800.5). FOR LARGER FIRES, USE WATER SPRAY, FOG OR REGULAR FOAM (1990 EMERGENCY RESPONSE GUIDEBOOK, DOT P 5800.5). FIREFIGHTING: MOVE CONTAINER FROM FIRE AREA IF YOU CAN DO IT WITHOUT RISK (1990 EMERGENCY RESPONSE GUIDEBOOK, DOT P 5800.5, GUIDE PAGE 53). EXTINGUISH USING AGENT SUITABLE FOR TYPE OF SURROUNDING FIRE. AVOID BREATHING VAPORS AND DUSTS. KEEP UPWIND. ------------------------------------------------------------------------------ TOXICITY LYSERGIC ACID DIETHYLAMIDE: 700 NG/KG ORAL-HUMAN TDLO; 2857 NG/KG ORAL-HUMAN TDLO; 857 NG/KG ORAL-HUMAN TDLO; 750 NG/KG INTRAMUSCULAR-HUMAN TDLO; 16 MG/KG INTRAVENOUS-RAT LD50; 50 MG/KG INTRAPERITONEAL-MOUSE LD50; 46 MG/KG INTRAVENOUS-MOUSE LD50; 300 UG/KG INTRAVENOUS-RABBIT LD50; 16 MG/KG SUBCUTANEOUS-GUINEA PIG LD50; 1800 UG/KG ORAL-WILD BIRD LD50; MUTAGENIC EFFECTS DATA (RTECS); REPRODUCTIVE EFFECTS DATA (RTECS). CARCINOGEN STATUS: NONE. LYSERGIC ACID DIETHYLAMIDE IS TOXIC PARENTERALLY. POISONING DUE TO PSYCHOTOMIMETIC AGENTS MAY AFFECT THE CENTRAL NERVOUS SYSTEM. PERSONS WITH EMOTIONAL DISTURBANCES OR ORGANIC BRAIN DISEASE MAY BE AT INCREASED RISK FROM EXPOSURE. CROSS TOLERENCE BETWEEN DIFFERENT PSYCHOTOMIMETIC AGENTS MAY OCCUR. INTERACTIONS WITH MEDICATIONS HAVE BEEN REPORTED. ------------------------------------------------------------------------------ HEALTH EFFECTS AND FIRST AID INHALATION: LYSERGIC ACID DIETHYLAMIDE: ACUTE EXPOSURE- INHALATION MAY CAUSE SYSTEMIC POISONING AS DETAILED IN ACUTE INGESTION. CHRONIC EXPOSURE- REPEATED EXPOSURE MAY CAUSE SYSTEMIC POISONING AS DETAILED IN CHRONIC INGESTION. FIRST AID- REMOVE FROM EXPOSURE AREA TO FRESH AIR IMMEDIATELY. IF BREATHING HAS STOPPED, PERFORM ARTIFICIAL RESPIRATION. KEEP PERSON WARM AND AT REST. TREAT SYMPTOMATICALLY AND SUPPORTIVELY. GET MEDICAL ATTENTION IMMEDIATELY. SKIN CONTACT: LYSERGIC ACID DIETHYLAMIDE: ACUTE EXPOSURE- NO DATA AVAILABLE. CHRONIC EXPOSURE- NO DATA AVAILABLE. 1 OHS13028 PAGE 003 OF 006 FIRST AID- REMOVE CONTAMINATED CLOTHING AND SHOES IMMEDIATELY. WASH AFFECTED AREA WITH SOAP OR MILD DETERGENT AND LARGE AMOUNTS OF WATER UNTIL NO EVIDENCE OF CHEMICAL REMAINS (APPROXIMATELY 15-20 MINUTES). GET MEDICAL ATTENTION IMMEDIATELY. EYE CONTACT: LYSERGIC ACID DIETHYLAMIDE: ACUTE EXPOSURE- SYSTEMICALLY ADMINISTERED PSYCHOTOMIMETICS MAY CAUSE MYDRIASIS. LYSERGIC ACID DIETHYLAMIDE MAY PRODUCE WEAKNESS OF ACCOMMODATION IN HUMANS AND PSYCHIC BLINDNESS IN ANIMALS. A SINGLE RESEARCH REPORT DESCRIBES SPONTANEOUS ACTION POTENTIALS WHICH APPEAR TO ORIGINATE IN THE RETINA AND ARE DETECTABLE FROM THE EYE, THE OPTIC NERVE AND THE OCCIPITAL VISUAL CORTEX IN SEVERELY POISONED CATS. NO OCULAR OR PERMANENT ALTERATION OF VISION HAS BEEN REPORTED. A TERATOGENIC EFFECT OF LYSERGIDE ON THE LENS HAS BEEN SHOWN TO RESULT FROM ADMINISTRATION OF LARGE DOSES TO PREGNANT MICE, CAUSING HISTOLOGICALLY OBSERVABLE ABNORMALITIES IN THE LENS EPITHELIUM SIMILAR TO EFFECTS PRODUCED BY X-IRRADIATION. CHRONIC EXPOSURE- NO DATA AVAILABLE. FIRST AID- WASH EYES IMMEDIATELY WITH LARGE AMOUNTS OF WATER OR NORMAL SALINE, OCCASIONALLY LIFTING UPPER AND LOWER LIDS, UNTIL NO EVIDENCE OF CHEMICAL REMAINS (APPROXIMATELY 15-20 MINUTES). GET MEDICAL ATTENTION IMMEDIATELY. INGESTION: LYSERGIC ACID DIETHYLAMIDE: ACUTE EXPOSURE- INGESTION OF PSYCHOTOMIMETIC AGENTS MAY CAUSE NAUSEA, VOMITING, OCCASIONAL DIARRHEA, SWEATING, HEADACHE, HYPERTENSION, TACHYCARDIA, TWITCHING, HYPERREFLEXIA, TREMORS AND INCOORDINATION. BILATERALLY DILATED AND REACTIVE PUPILS, NYSTAGMUS, AND PHOTOPHOBIA MAY OCCUR. VASODILATION, HYPOTENSION AND RESPIRATORY DEPRESSION MAY OCCUR AT DOSES OF 20-60 MG/KG. BRADYCARDIA MAY BE PRESENT AT HIGHER DOSES. CONVULSIONS AND COMA HAVE BEEN REPORTED. EFFECTS ON THE CENTRAL NERVOUS SYSTEM MAY INCLUDE EUPHORIA, HYPEREXCITABILITY AND ALERTNESS, RAMBLING SPEECH, DELIRIA, UNCONTROLLABILITY, TRANSCENDENTAL MOOD, DISTRACTABILITY, DEPERSONALIZATION AND IMPAIRMENT OF JUDGEMENT. A TEMPORARY PSYCHOTIC STATE WITH SENSORY ILLUSIONS, DISTORTIONS OR VISUAL HALLUCINATIONS CONSISTING OF SHIMMERING INTENSIFICATION OF COLOR AND TEXTURE, BRIGHTLY COLORED LIGHTS, GEOMETRIC DESIGNS, ANIMALS AND OCCASIONALLY HUMAN IMAGES MAY OCCUR. HEARING OR TASTING COLORS AND SEEING SOUNDS HAVE BEEN REPORTED. RARELY, ANXIETY, FEARFUL AUDITORY, VISUAL AND TACTILE HALLUCINATIONS, PANIC STATES AND PARANOID DELUSIONS, SUSPICIOUSNESS, EMOTIONAL LABILITY, INTENSE DEPRESSION, LOSS OF CONTROL, SUICIDAL IDEATION AND SELF DESTRUCTIVE OR AGGRESSIVE ACTS MAY OCCUR. DEATHS HAVE RESULTED FROM HALLUCINATORY EFFECTS LEADING TO ACCIDENTAL DEATH. ADDITIONAL EFFECTS DUE TO LYSERGIC ACID DIETHYLAMIDE MAY INCLUDE SALIVATION, LACRIMATION, HYPERPYREXIA, HYPERTENSION, PILOERECTION, SPASTIC PARESIS, HYPERACUSIS, SUGGESTIBILITY, PROLONGED PSYCHOSIS, RARELY, HYPERGLYCEMIA AND INTERNAL CAROTID ARTERIOSPASM WITH RESULTANT CEREBRAL ANOXIA AND SEIZURES. INFLAMMATORY FIBROSIS HAS BEEN REPORTED. STUDIES INDICATE THAT DEATH IN ANIMALS IS DUE TO RESPIRATORY FAILURE OR HYPERTHERMIA. IN THE HUMAN ADULT, LYSERGIC ACID DIETHYLAMIDE HAS BEEN ASSOCIATED WITH BREAKS AND OTHER STRUCTURAL ABNORMALITIES OF CHROMOSOMES. A SINGLE STUDY OF PREGNANCIES OCCURRING AFTER MEDICALLY ADMINISTERED DOSES DID NOT SHOW AN INCREASE IN THE RATE OF SPONTANEOUS ABORTIONS, PREMATURE BIRTHS, OR CONGENITAL DEFECTS OVER THE NORM. HOWEVER, BIRTH OF ABNORMAL BABIES HAS FOLLOWED CONSUMPTION OF ILLICIT LSD BY THE MOTHER IN EARLY PREGNANCY. 1 OHS13028 PAGE 004 OF 006 CHRONIC EXPOSURE- REPEATED EXPOSURE MAY CAUSE EFFECTS AS DETAILED IN ACUTE INGESTION. FLASHBACKS WITH HALLUCINATIONS AND DISTORTION OF PERCEPTION OF TIME, SPACE AND SELF IMAGE MAY OCCUR WEEKS OR MONTHS AFTER THE LAST DOSE. TOLERENCE AND PSYCHOLOGIC DEPENDENCE MAY OCCUR. FETAL LOSS HAS BEEN PRODUCED IN RATS FOLLOWING ORAL ADMINISTRATION OF 20 MICROGRAMS OF LYSERGIC ACID DIETHYLAMIDE BETWEEN THE FIRST AND FOURTH DAY OF GESTATION. NO SPECIFIC CONGENITAL DEFECTS WERE REPORTED. FIRST AID- TREAT SYMPTOMATICALLY AND SUPPORTIVELY. GET MEDICAL ATTENTION IMMEDIATELY. IF VOMITING OCCURS, KEEP HEAD LOWER THAN HIPS TO PREVENT ASPIRATION. ANTIDOTE: NO SPECIFIC ANTIDOTE. TREAT SYMPTOMATICALLY AND SUPPORTIVELY. ------------------------------------------------------------------------------ REACTIVITY REACTIVITY: STABLE UNDER NORMAL TEMPERATURES AND PRESSURES. INCOMPATIBILITIES: LYSERGIC ACID DIETHYLAMIDE: NO DATA AVAILABLE. DECOMPOSITION: THERMAL DECOMPOSITION PRODUCTS MAY INCLUDE TOXIC OXIDES OF CARBON AND NITROGEN. POLYMERIZATION: HAZARDOUS POLYMERIZATION HAS NOT BEEN REPORTED TO OCCUR UNDER NORMAL TEMPERATURES AND PRESSURES. ------------------------------------------------------------------------------ STORAGE AND DISPOSAL OBSERVE ALL FEDERAL, STATE AND LOCAL REGULATIONS WHEN STORING OR DISPOSING OF THIS SUBSTANCE. FOR ASSISTANCE, CONTACT THE DISTRICT DIRECTOR OF THE ENVIRONMENTAL PROTECTION AGENCY. **STORAGE** STORAGE OF CONTROLLED SUBSTANCES MUST COMPLY WITH APPLICABLE SECURITY REQUIRMENTS IN 21 CFR 1301.71, 1301.72, 1301.73, 1301.74, 1301.75 AND 1301.76. ------------------------------------------------------------------------------ CONDITIONS TO AVOID MAY BURN BUT DOES NOT IGNITE READILY. PREVENT DISPERSION OF DUST IN AIR. DO NOT ALLOW SPILLED MATERIAL TO CONTAMINATE WATER SOURCES. ------------------------------------------------------------------------------ SPILL AND LEAK PROCEDURES OCCUPATIONAL SPILL: DO NOT TOUCH SPILLED MATERIAL. STOP LEAK IF YOU CAN DO IT WITHOUT RISK. FOR SMALL SPILLS, TAKE UP WITH SAND OR OTHER ABSORBENT MATERIAL AND PLACE INTO 1 OHS13028 PAGE 005 OF 006 CONTAINERS FOR LATER DISPOSAL. FOR SMALL DRY SPILLS, WITH A CLEAN SHOVEL PLACE MATERIAL INTO CLEAN, DRY CONTAINER AND COVER. MOVE CONTAINERS FROM SPILL AREA. FOR LARGER SPILLS, DIKE FAR AHEAD OF SPILL FOR LATER DISPOSAL. KEEP UNNECESSARY PEOPLE AWAY. ISOLATE HAZARD AREA AND DENY ENTRY. ------------------------------------------------------------------------------ PROTECTIVE EQUIPMENT VENTILATION: PROVIDE LOCAL EXHAUST OR PROCESS ENCLOSURE VENTILATION SYSTEM. RESPIRATOR: THE FOLLOWING RESPIRATORS ARE RECOMMENDED BASED ON INFORMATION FOUND IN THE PHYSICAL DATA, TOXICITY AND HEALTH EFFECTS SECTIONS. THEY ARE RANKED IN ORDER FROM MINIMUM TO MAXIMUM RESPIRATORY PROTECTION. THE SPECIFIC RESPIRATOR SELECTED MUST BE BASED ON CONTAMINATION LEVELS FOUND IN THE WORK PLACE, MUST BE BASED ON THE SPECIFIC OPERATION, MUST NOT EXCEED THE WORKING LIMITS OF THE RESPIRATOR AND MUST BE JOINTLY APPROVED BY THE NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH AND THE MINE SAFETY AND HEALTH ADMINISTRATION (NIOSH-MSHA). ANY DUST AND MIST RESPIRATOR WITH A FULL FACEPIECE. ANY AIR-PURIFYING FULL FACEPIECE RESPIRATOR WITH A HIGH-EFFICIENCY PARTICULATE FILTER. ANY POWERED AIR-PURIFYING RESPIRATOR WITH A TIGHT-FITTING FACEPIECE AND HIGH-EFFICIENCY PARTICULATE FILTER. ANY TYPE 'C' SUPPLIED-AIR RESPIRATOR WITH A FULL FACEPIECE OPERATED IN PRESSURE-DEMAND OR OTHER POSITIVE PRESSURE MODE OR WITH A FULL FACEPIECE, HELMET OR HOOD OPERATED IN CONTINUOUS-FLOW MODE. ANY SELF-CONTAINED BREATHING APPARATUS WITH A FULL FACEPIECE OPERATED IN PRESSURE-DEMAND OR OTHER POSITIVE PRESSURE MODE. FOR FIREFIGHTING AND OTHER IMMEDIATELY DANGEROUS TO LIFE OR HEALTH CONDITIONS: ANY SELF-CONTAINED BREATHING APPARATUS THAT HAS A FULL FACEPIECE AND IS OPERATED IN A PRESSURE-DEMAND OR OTHER POSITIVE-PRESSURE MODE. ANY SUPPLIED-AIR RESPIRATOR THAT HAS A FULL FACEPIECE AND IS OPERATED IN A PRESSURE-DEMAND OR OTHER POSITIVE-PRESSURE MODE IN COMBINATION WITH AN AUXILIARY SELF-CONTAINED BREATHING APPARATUS OPERATED IN PRESSURE-DEMAND OR OTHER POSITIVE-PRESSURE MODE. CLOTHING: EMPLOYEE MUST WEAR APPROPRIATE PROTECTIVE (IMPERVIOUS) CLOTHING AND EQUIPMENT TO PREVENT REPEATED OR PROLONGED SKIN CONTACT WITH THIS SUBSTANCE. GLOVES: EMPLOYEE MUST WEAR APPROPRIATE PROTECTIVE GLOVES TO PREVENT CONTACT WITH THIS SUBSTANCE. EYE PROTECTION: EMPLOYEE MUST WEAR SPLASH-PROOF OR DUST-RESISTANT SAFETY GOGGLES TO PREVENT 1 OHS13028 PAGE 006 OF 006 EYE CONTACT WITH THIS SUBSTANCE. EMERGENCY EYE WASH: WHERE THERE IS ANY POSSIBILITY THAT AN EMPLOYEE'S EYES MAY BE EXPOSED TO THIS SUBSTANCE, THE EMPLOYER SHOULD PROVIDE AN EYE WASH FOUNTAIN WITHIN THE IMMEDIATE WORK AREA FOR EMERGENCY USE. ------------------------------------------------------------------------------ COPYRIGHT 1992 OCCUPATIONAL HEALTH SERVICES, INC.. ALL RIGHTS RESERVED. CREATION DATE: 07/29/88 REVISION DATE: 10/12/92 -- Darrell Fuhriman "Hi mom!"