From: [M d h] at [debug.cuc.ab.ca] Newsgroups: alt.drugs Subject: MDMA synthesis Date: 19 Nov 1993 18:12:36 -0600 Ok I just found this file a few days ago and I wanted to post it as to let the chemists look at it and tell me what they think. The reason why I post it is that this has to be one of the easier MDMA synthesis that I have seen, it requires readily available chemicals such as H2O2, formic acid, etc. but the formamide may be a little hardder to get. Please send all replies ot my mailbox as my Usenet feed is down. Thanks Manufacture of "Ecstacy" from Chemical Abstracts 52, 11965 (1958) For Informational Purposes Only. The authors & distributors do not advocate the use of illegal drugs and assume no liability for the use or misuse of this information . The procedures described are dangerous and should not be attempted by persons inexperienced in Organic Laboratory techniques. This formula is exemplified for MDA (3,4-Methylenedioxy- phenylisopropylamine); substituting N-methyl formamide results in MDMA or N-methyl MDA (Ecstacy). To a cooled mixture of 34 g 30% H2O2 and 150 g formic acid, add dropwise a solution of 32.4 g (0.2M) isosafrole in 120 ml acetone, (keep temperature below 30 degrees) Let stand twelve hours and evacuate in vacuum. Add 60 ml methanol and 369 g 15% sulfuric acid to the residue and heat on a water bath three hours. Cool, extract with ether or benzene and evaporate in vacuum the extract to give 20 g 3,4,-methylenedioxybenzylmethyl ketone. Add 23 g of above ketone to 65 g formamide and heat at 190 degrees for five hours. Cool, add 100 ml H2o2, extract with benzene and >>>See note about H2o2 below! evaporate in vacuum the extract. Add 8 ml methanol and 57 ml 15% HCL to residue, heat on water bath two hours and evaporate in vacuum (or basify with KOH and extract the oil with benzene and dry, evaporate in vacuum) to get 11.7 g MDA. The above occurs as a yellowish brown oil; this is active orally, but somewhat inconvenient; to convert to powder (salt) form, reflux in Hydrochloric acid and evaporate. Safrole, an allyl benzene, occurs naturally in oil of sassafras, about 70%. Can be extracted with simple distillation. It is con- verted to isosafrole (a propenyl benzene) by adding equal weight of KOH flakes and absolute ethanol and heating on steam bath or refluxing for 24 hours; dried and evaporated in vacuum or added with two time its volume in water and extracted with ether or methylene chloride and dried, evaporated in vacuum. Hexane is used for recrystalization. Formamide and N-methyl formamide are closely watched by the DEA. Many people have been busted by small suppliers where it was easy to get; those are "sting" operations that tail the buyer home. Mike Hamilton <[m d h] at [debug.cuc.ab.ca]> Newsgroups: alt.drugs From: [an 47455] at [anon.penet.fi] (bardeau) Date: Mon, 22 Nov 1993 07:29:31 UTC Subject: Re: MDMA synthesis > Ok I just found this file a few days ago and I wanted to post it as to >let the chemists look at it and tell me what they think. The reason why I post >it is that this has to be one of the easier MDMA synthesis that I have seen, >it requires readily available chemicals such as H2O2, formic acid, etc. but >the formamide may be a little hardder to get. Please send all replies ot my >mailbox as my Usenet feed is down. > > Thanks >Manufacture of "Ecstacy" >from Chemical Abstracts 52, 11965 (1958) > >To a cooled mixture of 34 g 30% H2O2 and 150 g formic acid, add >dropwise a solution of 32.4 g (0.2M) isosafrole in 120 ml acetone, >(keep temperature below 30 degrees) Let stand twelve hours and >evacuate in vacuum. Add 60 ml methanol and 369 g 15% sulfuric >acid to the residue and heat on a water bath three hours. Cool, >extract with ether or benzene and evaporate in vacuum the extract >to give 20 g 3,4,-methylenedioxybenzylmethyl ketone. > >Add 23 g of above ketone to 65 g formamide and heat at 190 degrees >for five hours. Cool, add 100 ml H2o2, extract with benzene and >evaporate in vacuum the extract. Add 8 ml methanol and 57 ml 15% rest of text deleted. Beware. This is a misprint, and a potentially dangerous one, in the Chemical Abstracts. In the cited reference, CA 52:11965 (1958) the phrase appears that states as noted above, "is heated at 190 C 5 hrs, cooled, 100 cc H2O2 added, extracted with benzene, the extract evaporated," etc. That was an abstract of the Japanese patent 8593 ('56). Somewhat earlier, two of these three authors published this chemical information in J. Pharm. Soc. Japan in two papers, Vol. 74 975-7, 977-80 (1954) and the Chemical Abstracts of this publication (CA 49:10958 (1955) give an almost identical set of chemical directions, which reads, "heated 5 hours at 190, the solution cooled, 100 ml water added, the mixture extracted with benzene, the extract evaporated," etc. In this presentation, the diluting solvent was water, not hydrogen peroxide. Water is the correct term. The addition of hydrogen peroxide to an organic mixture is intrinsicly dangerous, especially when there is the thermal removal of solvent ------------------------------------------------------------------------- To find out more about the anon service, send mail to [h--p] at [anon.penet.fi.] Due to the double-blind, any mail replies to this message will be anonymized, and an anonymous id will be allocated automatically. You have been warned. Please report any problems, inappropriate use etc. to [a--m--n] at [anon.penet.fi.]